Hyperlipidemia plays a strong role in coronary artery disease and is the second major risk factors in our population in Isfahan. This study ' investigated the effect of CARDIAC REHABILITATION on serum lipids. Methods: Our group in the CARDIAC REHABILITATION center chose a group of 120 patients who were referred after CARDIAC surgery or post- MI and followed them for 2 months. 60 patients participated in CARDIAC REHABILITATION program containing 24 exercise sessions (45-60 minute/ session), dietary consultation and mental health and 60 patients (control group) being the same as the intervention group in age, socio-economic status, serum lipids profile, history of coronary heart disease and other risk factors who didn’t participate in CARDIAC REHABILITATION program because of begin far from this center or other reasons. At first the 14hour fasting blood samples of two groups were sent for serum total cholesterol (T.Cho), triglycerides (TG), LDL-cholesterol (LDL-C), HDL-cholesterol (HDL-C) and in the same manner12 weeks later, the same samples were taken and measured the following data was obtained using students test.Results: T Cho, TG and LDL-C of intervention group has decreased in 70%,62% and 76% of patients and in 86% patients, HDL-C showed an increase. T.coh, TG, LDL-C and HDL-C was normalized in 35%, 30%, 68% and 66%, respectively after finishing their 2 month course which overall showed a 20, 56, and 30 mg/dl reduction in serum lipids respectively and 0.8 reduction in LDL-C / HDL_C (P<0.05) and 5 mg / dl increase serum HDL-C (P<0.05) in intervention group vs. control group. Discussion: The decrease in T.cho, TG and LDL-C and increase in HDL-C in all patients and normalization of lipid profile in most of them shows the importance of REHABILITATION in CARDIAC patients and the need for its continuity.